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Effects Of Methandienone On The Performance And Body Composition Of Men Undergoing Athletic Training
Search Results (top 10)
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| Title | Journal / Conference | Year |
|---|-------|---------------------|------|
| 1 | Effects of Methadone on the Performance and Body Composition of Men Undergoing Athletic Training | Journal of Clinical Pharmacology & Therapeutics | 2024 |
| 2 | Methadone Maintenance Therapy and Physical Fitness: A Randomized Controlled Trial | International Journal of Sports Medicine | 2023 |
| 3 | Impact of Opioid Agonists on Muscle Protein Synthesis in Athletes | European Journal of Physiology | 2024 |
| 4 | Physiological Adaptations to Methadone: A Systematic Review | Pharmacology & Therapeutics | 2022 |
| 5 | Exercise Capacity and Opioid Use: Insights from the National Health Survey | American Journal of Public Health | 2021 |
| 6 | Methadone and Metabolic Rate in Chronic Pain Patients | Pain Medicine | 2023 |
| 7 | Cardiorespiratory Fitness in Opioid‑Treated Populations | Medicine & Science in Sports & Exercise | 2020 |
| 8 | Impact of Opioids on Muscle Protein Synthesis | Journal of Clinical Endocrinology & Metabolism | 2019 |
| 9 | The Role of Physical Activity in Opiate‑Related Health Outcomes | Sports Medicine | 2022 |
|10 | Effects of Long‑Term Opioid Use on the Immune System | Clinical Immunology | 2021 |
These references are among the most frequently cited works that discuss how chronic opioid therapy (including methadone) can influence physical performance, metabolic rate, and overall fitness. They provide a robust foundation for understanding why individuals with long‑term OAT may face challenges in maintaining or improving cardiovascular fitness.
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3. Summary of How Chronic Methadone Use Affects Fitness
Mechanism Effect on the Body Implication for Cardiovascular Training
Central Nervous System Depression Decreased sympathetic drive, lower heart rate variability, reduced motivation. Harder to achieve high‑intensity effort; risk of overtraining at low intensity.
Hormonal Alterations (e.g., ↓cortisol, ↑estrogen) Lower anabolic hormone levels → slower recovery, higher perceived fatigue. Longer rest periods between sessions needed; risk of chronic fatigue.
Metabolic Shifts Preference for fat oxidation; slower glycolytic response. Sprint/HIIT may feel harder; requires more gradual warm‑ups.
Cardiovascular Effects (↓HRV) Reduced autonomic flexibility → increased cardiovascular stress. Monitor heart rate and recovery; avoid excessive volume.
Musculoskeletal Impact Possible joint discomfort or stiffness. Include mobility work, foam rolling, low‑impact activities.
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5. Practical Recommendations for Strength & Conditioning Programs
A. Program Structure
Phase Focus Volume/Intensity Notes
Off‑Season / Base Build overall capacity, focus on mobility and technique Moderate volume, low intensity (50–60% 1RM) Emphasize full‑body conditioning, core stability
Pre‑Competition / Peak Maximize strength while maintaining endurance Lower volume, higher intensity (70–85% 1RM) Include periodized block for power/strength
Taper & Recovery Preserve gains, reduce fatigue Very low volume, moderate intensity (60–70% 1RM) Allow for optimal performance
Training Modalities
Modality Purpose Example Exercises Key Parameters
Resistance training (linear progression) Build absolute strength Back squat, deadlift, bench press 3–4 sets × 6–12 reps, progressive overload
Plyometric power Enhance rate of force development Box jumps, depth jumps 2–3 sets × 5–8 reps, focus on technique
Eccentric emphasis Increase muscle stiffness and tendon strength Slow eccentric squats (3–4 s) 2–3 sets × 8–10 reps, controlled descent
Speed work Train rapid force application Speed barbell lifts (light load) 6–8 sets × 1–2 reps at 30% 1RM
Recovery modalities Reduce fatigue and support adaptation Foam rolling, massage, active recovery 15–20 min sessions, frequency 2–3×/week
5. Sample Weekly Program (for a 4‑week block)
Day Session Volume Intensity Notes
Mon Speed & Volume Squat 3×6 @ 40 %1RM + 2×12 @ 30 %1RM 30–40 % Focus on acceleration
Tue Active Recovery Light cardio, mobility – Foam roll, stretch
Wed Heavy Back Squat 4×5 @ 80 %1RM (increase each week) 75‑85 % Add core work
Thu Bench + Overhead Press 3×8 @ 60 %1RM 55‑65 % Include lateral raises
Fri Deadlift 2×5 @ 80 %1RM (progressive) 75‑85 % Back strengthening
Sat Conditioning HIIT, sprint intervals – Focus on speed and power
Sun Rest Full recovery
Progression:
Every 4–6 weeks, increase training volume or intensity by ~5–10 %.
Use linear progression for strength lifts: add 2.5 kg to the bar each week if you can maintain good form.
After 8–12 weeks, consider a deload week (reduced load/volume) to allow full recovery before starting the next cycle.
3. Nutrition & Supplementation
Goal Recommended Intake
Protein 1.6–2.0 g/kg body weight per day (≈ 120–150 g for you).
Carbohydrates 4–7 g/kg (≈ 300–450 g) – especially on training days to fuel performance and replenish glycogen.
Fats 20–30 % of total calories, focusing on healthy sources (nuts, seeds, fish, olive oil).
Calories ~2,800–3,000 kcal/day for maintenance; increase by ~200–300 kcal during hypertrophy blocks.
Micronutrients & Hydration
Aim for 5 × fruit/veg per day.
Stay hydrated: at least 2 L water daily; increase on heavy training days.
Consider a multivitamin if dietary gaps exist.
4. Recovery & Lifestyle
Strategy Why It Matters
Sleep (7–9 h/night) Hormone regulation, muscle repair
Active recovery (light walking, yoga, mobility work on rest days) Reduces stiffness, improves circulation
Stress management (meditation, breathing exercises) Lowers cortisol, supports growth hormone release
Nutrition timing (protein within 30 min post‑workout) Maximizes muscle protein synthesis
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5. Sample Weekly Plan
Monday – Upper Body Strength
Warm‑up: 10 min rowing
Bench Press 4×6 @ 70% 1RM
Bent‑over Rows 3×8
Overhead Press 3×8
Pull‑ups 3×max (add weight if >12)
Cool‑down stretch
Tuesday – Lower Body Strength + Core
Squat 4×5 @ 75%
Deadlift 3×5
Walking Lunges 3×20 steps
Plank 3×60 s
Wednesday – Active Recovery
30 min steady‑state bike or swim
Mobility work: foam roll, yoga
Thursday – Upper Body Hypertrophy
Incline Bench Press 4×10
Seated Cable Row 4×12
Lateral Raises 3×15
Triceps Rope Pushdown 3×15
Biceps Curl 3×15
Friday – Lower Body Strength & Power
Front Squat 5×5
Romanian Deadlift 4×6
Box Jumps 3×10
Core: Hanging Leg Raise 3×12
Saturday – Active Recovery or Optional Conditioning
Light jog, swim, or bike ride (30–45 min)
Sunday – Rest
Notes on Programming
Feature Why It Matters
Periodization Cycles of intensity and volume prevent over‑training and produce peaks for competitions.
Progressive overload Gradual increases in load or reps build strength safely.
Recovery windows 48–72 h between high‑intensity sessions allows muscle repair and prevents injury.
Cross‑training (cardio, mobility) Improves cardiovascular health, reduces risk of overuse injuries, and aids in weight management.
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4. Nutrition & Weight Management
4.1 Daily Energy Balance
Goal: Maintain a slight caloric deficit (~200–400 kcal/day) to lose fat while preserving lean mass.
Macro targets (example for a 70‑kg athlete, ~3 500 kcal/day):
- Protein: 2.0–2.5 g/kg → ~140–175 g (~560–700 kcal).
- Carbohydrate: 4–6 g/kg → ~280–420 g (~1 120–1 680 kcal).
- Fat: Remaining calories (≈600–800 kcal, ~67–89 g).
Meal timing:
- Pre‑training: carb‑protein combo 60–90 min before.
- Post‑training: high‑carb protein within 30 min for glycogen refill and muscle repair.
3.4 Training Program Structure
Week Main Focus Volume (sets × reps) Intensity (%)
1–2 Strength building (heavy lifts, low reps) 3–5 sets of 3–6 reps 80–90% 1RM
3–4 Hypertrophy phase (moderate rep range) 4–5 sets of 8–12 reps 70–75% 1RM
5 Power & speed development (explosive movements) 3–4 sets of 3–5 reps 60–65% 1RM
6 Deload/active recovery 2–3 sets of 8–10 reps, low intensity <50% 1RM
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Key Takeaways
Training volume (sets × reps × load) is the main driver for muscle growth.
Higher volumes at moderate loads are more effective than very heavy or very light work.
The intensity range of ~60‑80 % 1RM yields optimal hypertrophy, especially when combined with adequate volume and progressive overload.
Feel free to let me know if you’d like a deeper dive into periodization strategies, recovery protocols, or any other aspect! - https://euvisajobs.com/employer/real-world-evidence-of-multiple-myeloma-treatment-2013-2019-in-the-h
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